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Auricularia auricula mushroom6/26/2023 Polysaccharides from Auricularia auricula-judae extract include carbohydrate mainly composed of rhamnose, xylose and glucose and smaller amount of mannose, galactose and arabinose, uronic acids, sulfate groups, N and ash (Chen et al., 2008) and its active constituents are beta (1-3) and (1-6) D glucans. Fruit bodies of Auricularia auricula- judae are rich in carbohydrates, protein and minerals (Ca, P and Fe). ![]() The species of agaricus, pleurotus, lentinus, ganoderma, grifola, volvariella, auricularia and tremella genera are the most popular in mushroom industry for their medicinal and nutritional values.Īuricularia auricula-judae is well known as wood ear or tree ear or black fungus. Antitumor activities of these mushrooms have been extensively investigated due to recent chemotherapeutic application of some antitumor drugs derived from natural sources and will continue to occupy an important role in modern cancer therapy (Wasser and Weis, 1999). Among medicinal mushrooms, basidiomycetes contain highly potent polysaccharides and protein complexes that have as antitumor, immunomodulation, anticardiovascular diseases and hypocholesterolemia, antiviral, antibacterial and antiparasitic activities. Medicinal mushrooms have been in the interest of many researchers for their pharmacological effects as well as for their nutritional value. Thus, the results indicated the dichloromethane fraction may have potential ingredients as antitumor candidates. The splenomegaly and higher splenic index were found in tumor-bearing mice, with the DCM fraction returning to the negative control values. The potent antitumor effect of the dichloromethane (DCM) fraction was also found against solid tumor in BALB/c mice. IC 50 value of dichloromethane fraction was 94.2 μg/m l against sarcoma 180 cells lower than any other solvent fractions. These cytotoxic effects of all the tested fractions were confirmed on the MTT and SRB assays, without statistical differences each other. ![]() A dose-dependent antitumor activity of each solvent fraction (from 0.01 mg/m l to 0.3 mg/m l) was shown against both cell types. ![]() The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells.
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